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Chargers vs Chiefs Prediction & Picks: NFL Week 6

Andy Reid off a bye. Ryan Kramer said it, then said it again, and by the end of the segment Sean Green was quoting the same rule back at him. The Chargers visit the Chiefs on Sunday, October 18 at 4:25 PM ET in Kansas City, MO, with the Chiefs 8-point favorites and a total of 42.5 when the guys taped on October 14. Both hosts landed on Kansas City on the NFL Picks Week 6 episode.

Chargers vs Chiefs Odds

The Chiefs were 8-point favorites over the Chargers with a total of 42.5 when the guys taped on October 14. On the money line it was Chiefs -420 and Chargers +340.

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Sean came in with the case for the dog and talked himself out of it. Division dogs have been good this season, he said, and he noted Herbert has a strong record against the spread as an underdog of six or more. If Kansas City weren’t coming off the bye, eight points in a division game is a number he’d probably take with the Chargers. What stopped him was the Chargers’ offensive line. He called it one of the big trench mismatches of the week and said he doesn’t see how they get a running game going, on top of a roster he described as incredibly banged up.

Ryan’s argument was blunter: the Chargers are bad, and it’s Mahomes and Reid with an extra week. He dug into what he called micro matchups. Kansas City’s defense plays a lot of man coverage, and by his read the Chargers have struggled against man. He also liked the Chiefs’ run game against a defense he said has been missing tackles. Mahomes, he added, comes off the bye feeling healthier than he’s felt.

The worry was the number. Sean said Mahomes as a big favorite has not been a good bet, calling him the king of winning and not covering, a point Ryan had already raised about the Chiefs and big numbers. They shrugged and called it the donkey play of the week. Sean’s closing line: any time he bets against Andy Reid coming off a bye, he feels dumb for it.

Hear the full breakdown on the NFL Picks Week 6 episode, or listen on Apple Podcasts and Spotify. Watch every game on YouTube, and download the SGPN app at sg.pn/links. See all our NFL Picks.

Listen to the full episode

More Week 6 NFL Picks

Seahawks vs Broncos

Texans vs Jaguars

Jets vs Patriots

Steelers vs Buccaneers

Ravens vs Browns

Bears vs Falcons

Titans vs Colts

Panthers vs Eagles

Saints vs Giants

Cardinals vs Rams

Bills vs Raiders

Cowboys vs Packers

Commanders vs 49ers

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