Wake Forest vs Louisville Prediction & Picks: College Football Week 4

The underdog had the better story in this one. Wake Forest brings what Colby Dant considers one of the best coaching staffs in the sport, plus a playmaker who should be healthier than he was a week ago, into a spot where Louisville may still be celebrating. Kickoff is Saturday, September 26 at 9:00 AM PT / 12:00 PM ET in Louisville, KY, and the guys took the points at Wake Forest +12.5 with the total at 58.5. Catch the full segment on the College Football Picks Week 4 episode.

Wake Forest vs Louisville Odds

On the show, Louisville was -12.5 with a total of 58.5. The line has since moved to Louisville -11.5, total 57.5.

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Colby started with Lopez. He got hurt in the Purdue game and couldn’t run against Miami, and Colby says he usually runs for 60 or 70 yards. There were plenty of snaps where Miami brought pressure and the lanes were open, and with a healthy Lopez, Colby thinks he really could have been a problem. As for the staff, Colby noted they’re North Dakota State guys who won nine games in their first season, and he’d argue they should have had ten.

The Louisville side of it, per Colby, is a letdown. That was Louisville’s first time beating SMU, a huge game, and now comes what looks like an easy week against a chippy Wake team. He also brought up Louisville’s habit of losing as a heavy favorite, pointing to a loss to Cal after a cross-country trip and another to UVA. He liked Wake enough to call the money line a crazy play worth a look.

Ryan found the number itself persuasive. Wake lost to Miami by 13 last week, and the spread here is about the same. Louisville then has NC State and Florida State, which he called a letdown sandwich, and he labeled Wake an obvious spot to take the dog. One of the guys added that Wake adjusted in the second half against Miami, which he read as good coaching, and that the run game looked solid.

Hear the full breakdown on the College Football Picks Week 4 episode, or listen on Apple Podcasts and Spotify. Watch every game on YouTube, and download the SGPN app at sg.pn/links. See all our College Football Picks.

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