Patriots vs Seahawks Prediction & Picks: NFL Week 1

The 2026 NFL season kicks off Wednesday night with a Super Bowl rematch, and the guys handicapped Patriots vs Seahawks on NFL Picks Week 1. Seattle sits as a 3-point home favorite with the total at 44. The full slate breakdown is in the NFL Picks Week 1 episode.

Patriots vs Seahawks Odds

Seattle Seahawks -3 (New England Patriots +3)
Total: 44
Moneyline: Seahawks -184, Patriots +155

Seattle laying just three at home is the part the guys kept coming back to on the show. This was a neutral-field 4.5 when they graded the matchup back in the spring, and the number has since come in a point and a half toward New England. That is reverse movement into one of the loudest home fields in the league, and neither host could make it add up.

Our Picks

Both hosts are on the same side of this one.

Ryan Kramer (@KramerCentric): Seattle Seahawks -3
Sean Green (@SeanTGreen): Seattle Seahawks -3

The case starts with history: Super Bowl losers have opened poorly against the number, and worse on the road, while champs coming off a title tend to hold serve at home. From there it’s the trenches. Seattle’s front four already gave New England trouble the first time these teams met, and the guys still have questions about the Patriots protecting Drake Maye. Stack in a Seahawks team that is a tough out early at home and Mike McDonald’s record as a favorite, and both landed on laying the three in the opener.