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49ers vs Cowboys Prediction & Picks: NFL Week 10

San Francisco uses pre-snap motion more than any team in the league, Sean Green (@SeanTGreen) said, and Dallas gives up the most EPA against it. That mismatch drives the 49ers vs Cowboys pick on the NFL Picks Week 10 episode, and Sean and Ryan Kramer (@KramerCentric) ended up on the same side. The 49ers were 4-point favorites with a total of 56 when the guys taped on November 11, and both of them played the 49ers -4. Kickoff is Sunday, November 15 at 4:25 PM ET in Arlington, TX.

49ers vs Cowboys Odds

The 49ers were 4-point favorites over the Cowboys with a total of 56 when the guys taped on November 11. Ryan read the money line on air at 49ers -215 and Cowboys +185.

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Ryan started with Kyle Shanahan, whom he called arguably the best offensive coordinator in the NFL at putting linebackers and safeties into conflict. He expects communication issues for a Cowboys defense he described as banged up at linebacker and safety. He also thinks the pieces San Francisco added on defense will make it hard for Dallas to run. His final score was 31-21.

Sean said Brock Purdy kind of owns the Cowboys, and the guys noted he is 3 and 0 straight up and against the spread in three games against them. Ryan called Purdy one of the best processors in the league. He said the tape on the Dallas defense shows open receivers every week, and the Cowboys look better only when the quarterback misses them.

When Ryan asked for the Cowboys case, Sean offered the home-dog angle and the Dallas offense. He allowed that Kirk Cousins and his offense moved the ball against the 49ers. He still came back to the matchup: San Francisco gets stops when it needs them and generates turnovers, while the Cowboys have been sloppy with the football. “This isn’t even the hater in me,” he told Ryan.

Ryan added one more worry for Dallas. He senses friction over what the team wants to do with George Pickens, between the front office and the coaches and between the players and the coaches.

Hear the full breakdown on the NFL Picks Week 10 episode, or listen on Apple Podcasts and Spotify. Watch every game on YouTube, and download the SGPN app at sg.pn/links. See all our NFL Picks.

Listen to the full episode

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Commanders vs Giants

Patriots vs Lions

Bills vs Jets

Jaguars vs Titans

Dolphins vs Colts

Chiefs vs Falcons

Texans vs Browns

Panthers vs Saints

Vikings vs Packers

Seahawks vs Raiders

Rams vs Cardinals

Steelers vs Bengals

Chargers vs Ravens

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