It’s hard to believe it’s Week 4 of College Football action already. The season has been flying by, and more and more conference matchups are taking place. Week 3 was once again filled with upsets. West Virginia took down their rivals at Virginia as 10.5-point dogs. Oklahoma staved off a New Mexico upset bid. Kentucky pulled a big upset over Texas A&M in the SEC. Now, we’ll do our best to find the best College Football upsets in Week 4 as we build our College Football upset parlay.
Tennessee (+170)
The matchup of the weekend: the battle of orange, two blue-bloods, two SEC teams looking to establish themselves. Texas already knocked off #1 Ohio State and stole the top spot for themselves. But they did that in the friendly confines of Darrell K Royal Stadium. And it took a choke job from the Buckeyes and a massive comeback from the Longhorns to win that one. Now, they have to go on the road. Deep into hostile SEC territory at Neyland Stadium with a Volunteer crowd that’ll be rocking the place. Just like the home-field advantage helped Texas when #1 came to town, now Tennessee gets that advantage.
Archie Manning and his Longhorns struggled big time on the road last season. They lost 14-7 at Ohio State. Then in the SEC schedule, a bad Florida Gators team took them down at The Swamp. The Kentucky Wildcats took them to overtime, as did the Mississippi Bulldogs. In both games, Texas was favored by well over a touchdown. Georgia stomped them in Athens 35-10. Yes, this team beat Ohio State, but again, it took the comeback to do it. They’ve earned the #1 ranking for now, but they need to prove they are the #1 team this week, and we’ve yet to see that outside of the friendly confines of home.
Tennessee has a legit two-headed monster in the running game with DeSean Bishop and Daune Morris. Faizon Brandon, the freshman Tennessee quarterback, will be the difference in this one. He’s been efficient so far this season, but hasn’t faced a defense like Texas. If he can manage this game and let the run game and Volunteer defense do their thing, the Volunteers can take down this #1 team.
Iowa (+175)
As much as I personally do not like the Iowa Hawkeyes being a Nebraska fan, this is my favorite upset on the board. This Michigan team has clearly shown they are beatable. Western Michigan went into The Big House and took them down. Michigan made the most of their free second, but we all saw them lose. Now, you send Kirk Ferentz and his ruthless defense in there, and this is absolutely an upset spot.
Through three games, Iowa is allowing just 4.3 points and 176.7 yards per game, both currently best in the country. The Hawkeyes have allowed only one touchdown in 12 quarters and have two shutouts. They’re also allowing just 66 rushing yards per game. This is the entire key for the Hawkeyes in this one. Control the game, slow it down, and force Michigan into mistakes. Ferentz has seven wins against Michigan, including beating them twice on the road.
Ole Miss (+135)
Trinidad Chambliss. That’s really all that needs to be said. Chambliss is coming off a 363-yard, two-touchdown passing performance against LSU, and he’s now thrown for 924 yards with seven touchdowns and only two interceptions through three games. He’s completing 70% of his passes and has added two rushing touchdowns. By the way, those aren’t against FCS teams. Ole Miss has beaten two ranked teams already this year. Ole Miss just pulled off the upset of all upsets over their former head coach.
The biggest hurdle for them will be not letting the victory hangover creep in. If they can keep that away and take this same energy into The Swamp, the Gators better watch out. Florida is 3-0 and off to a good start, but unlike Ole Miss, they aren’t as sharp as the Rebels when it comes to being battle-tested in 2026. Florida’s secondary allowed 271 passing yards to Auburn last week. Ole Miss will focus in on the dangerous rushing attack of the Gators, and if they can slow down Jadan Baugh, it’ll be key in the Rebels winning this one.
Tennessee + Iowa + Ole Miss Parlay: +1645
