It’s time for my top NFL Week 6 props! With a loaded slate of action, I’m breaking down my favorite prop bets for this weekend. In fact, I feel so good about these prop bets that I’m loading them into a parlay! Let’s take a look at some of the top players that I’m taking this weekend.
Top 2026 NFL Week 6 Props
Drake London Over 100 Receiving Yards (+134)
Drake London enters this matchup as one of the hottest receivers in the league, and I expect him to clear 100 receiving yards against the Bears. Through five games, London has already racked up 488 yards on 27 catches, averaging 97.6 yards per game.
He posted 194 yards against the Packers, followed by 98 against the Saints and 118 in an overtime loss to the Ravens. That recent stretch shows consistent volume and big-play ability with Michael Penix under center.
The Bears’ secondary faces a tough test here. London averages 18.1 yards per reception and creates after-the-catch yards. Atlanta’s offense relies heavily on him as the primary target. Chicago’s pass defense has shown vulnerabilities against physical outside receivers. This is also a home game for the Falcons, giving them a friendly environment.
Penix will continue to look his way often, and the plus-money price of +124 offers solid value on a player averaging close to 100 yards against a bad Bears defense. I like London to produce another big afternoon and cash this prop easily as part of my NFL Week 6 props card.
Caleb Williams Over 18.5 Rushing Yards (-110)
Caleb Williams returns from a hamstring injury this week, which is why this number is so low. In his two appearances earlier this season, Williams has accumulated 107 rushing yards. The low line of 18.5 is due to the injury. However, his mobility is an important part of his game, and he has been moving around great in practice.
Bears head coach Ben Johnson may not draw up designed runs for Caleb. However, Atlanta’s defense allows mobile quarterbacks to pick up yardage on scrambles. With a fresh start after missing time, and a pissed-off Caleb Williams, there should be plenty of opportunities. I’m a Bears fan, so take it for granted, but I had to put this on my NFL Week 6 props card.
Marvin Harrison Over 21.5 Receiving Yards (-113)
Marvin Harrison Jr. makes his Houston Texans debut in London, and I like him to clear a modest 21.5 receiving yards. Harrison posted just 85 yards on five catches in four games with Arizona. However, this trade reunites him with his college quarterback, C.J. Stroud.
That connection should unlock more targets immediately. Head coach DeMeco Ryans confirmed Harrison will play. I don’t expect him to have a career game. However, I do think they will work him in on some designed plays, especially after giving up a second-round pick.
The Jaguars’ secondary ranks among the league’s weaker units against the pass, and Harrison’s past 17 yards-per-catch average shows he can win downfield. Even a couple of targets should push him over this slow number.
Stroud has the arm talent to feed his former teammate early and often in this international matchup. Plus, the defense has to focus on Nico Collins, leaving Harrison with single coverage.
Blake Corum Over 42.5 Rushing Yards (-110)
Blake Corum should top 42.5 rushing yards in a favorable matchup against the Arizona Cardinals. The Rams’ backup back has carried the ball 38 times for 181 yards this season, averaging 4.8 yards per carry and 36 yards per game.
He scored his first touchdown of the year last week against Buffalo while also contributing in the pass game. Although Kyrne Williams remains the lead back, Corum consistently earns meaningful touches in a complementary role.
Arizona ranks near the bottom of the league against the run, and the Rams enter as heavy home favorites. That script typically leads to more opportunities for the backup in the second half. Corum has shown efficiency and burst when given the ball, including a 79-yard performance earlier this season. The line of 42.5 sits around his average, and a slightly expanded workload against a soft front seven should get him there. I am adding this one to my NFL Week 6 props parlay card.
Kenneth Walker III 100+ Rushing Yards (+128)
Kenneth Walker III looks like a strong bet to hit 100 rushing yards against the struggling Los Angeles Chargers. The Chiefs’ new workhorse has exploded for 537 yards on 87 carries through four games, averaging an elite 134.3 yards per game and 6.2 yards per carry.
He posted 173 yards against Denver, 117 against the Colts, and 177 against the Raiders. Kansas City’s offense has run through Walker, and he handles a heavy workload every week.
The Chargers enter at 0-5 with a porous run defense that struggles to stop productive backs. Wlaker’s combination of volume and efficiency makes him a nightmare matchup, especially at home against the 4-0 Chiefs, who are coming off a bye. The +128 price on 100-plus yards offers excellent value given his season average. He has already cleared 100 yards in three of four games.
