Eight more teams look to punch their tickets to the Sweet Sixteen, as the Second Round of the NCAA Tournament concludes tomorrow. For my best bet for Sunday, March 22nd: March Madness Second Round Predictions, we’re heading to the Enterprise Center in St. Louis, Missouri, for Midwest Region Second Round action. Let’s get this money!
Best Bet For Sunday (March 22nd): March Madness Second Round Predictions
#7 Kentucky Wildcats vs #2 Iowa State Cyclones
Start Time: 2:45 PM EST
There aren’t many playable spreads for tomorrow’s eight Second Round games – in fact, there is only one game that I’m going to make a play on. And that is this one, with the #7 Kentucky Wildcats of the SEC up against the #2 Iowa State Cyclones from the Big 12.
I was in on the Cyclones in their First Round game, when they smoked the Tennessee State Tigers and covered the spread for me. The Wildcats had a tougher go of it in their first game, needing overtime to get past the Santa Clara Broncos.
And I’m in on Iowa State against Kentucky, as well. A much better offense and a light year’s better defense have the Cyclones rated way higher than the Wildcats in my eyes. My line for this game is Iowa State -7.5, so I’ll take the Cyclones laying the points as my best bet for Sunday.
Best Bet: Iowa State -4.5 (-110)
Best Bet Overall 2026 Record: 52-28 (65%)
Profit (based on $100/bet): $1,230.24
Return on Investment: 15%
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