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Buffalo Bills vs. New Orleans Saints NFL Betting Preview for Week 12

The New Orleans Saints (5-5) are an underdog by 4.5 points as they look to halt a three-game slide in a matchup with the Buffalo Bills (6-4) on Thursday, November 25, 2021 at Caesars Superdome. The point total is set at 46.5.

Bills Vs. Saints Odds

Bills vs Saints Betting Information
Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
Bills -4.5 -109 -110 46.5 -110 -110 -212 +173

Bills and Saints: Last Three Games

  • Buffalo is 1-2-0 against the spread and 1-2 overall in its past three games.
  • The Bills and their opponents have hit the over two times in those games.
  • The past three Bills games averaged 2.3 more points (48.8) than this matchup’s over/under.
  • New Orleans covered the spread once in its past three matchups while putting up a 0-3 record straight-up in those games.
  • The final combined score of the past three Saints games has exceeded the set total each time.
  • The last three Saints games averaged 42.7 total points, 3.8 fewer points than this matchup’s over/under.

Bills and Saints: Betting Trends

  • Buffalo has covered the spread five times over 10 games with a set spread.
  • The Bills are 3-4-1 ATS when playing as at least 4.5-point favorites.
  • Buffalo’s games have gone over the total five times this season.
  • The Bills have won five of the nine games they were the moneyline favorite this season (55.6%).
  • In games it has played as a moneyline favorite with odds of -212 or shorter, Buffalo has a 4-4 record (winning 50% of its games).
  • The Bills have a 67.9% chance to win this matchup based on the moneyline’s implied probability.
  • New Orleans is 5-5-0 against the spread this year.
  • This season, six of New Orleans’ games have gone over the point total.
  • The Saints have won three of the five games they’ve played as underdogs this season.
  • New Orleans has not entered a game this season as a bigger underdog on the moneyline than the +173 odds on them winning this game.


Over/Under Trends

  • This season, five of Buffalo’s 10 games have gone over Thursday’s total of 46.5 points.
  • This season, five games New Orleans played finished with a combined score higher than 46.5 points.
  • Together, the two teams combine for 54.6 points per game, 8.1 points more than the total of 46.5 for this matchup.
  • This matchup’s total is 7.1 fewer points than the 39.4 these two teams combine to give up per game in 2020.
  • This season, the average total for Bills games is 49.4 points, 2.9 more than the over/under of 46.5 points for this contest.
  • The over/under for this contest is 2.3 points more than the average over/under in Saints’ games this season (44.2 points).

Bills Players to Watch

  • Josh Allen is the No. 2 fantasy player overall and the No. 2 fantasy quarterback with 232.4 points (averaging 23.2 per game).
  • Stefon Diggs has put up 113.3 fantasy points this year (11.3 per game), enough to rank him 49th overall and eighth among receivers in league-wide fantasy standings.
  • So far this season, Emmanuel Sanders’ 80.2 total fantasy points make him the No. 89 fantasy player and No. 30 receiver. He averages 8.0 fantasy points per game.
  • Zack Moss is the 105th-ranked fantasy player — and the 32nd-ranked running back — with 71.1 fantasy points. He averages 7.1 fantasy points per game.

Saints Players to Watch

  • So far this season, Alvin Kamara is 40th overall among all players and 10th among all running backs with 126.0 fantasy points (12.6 per game).
  • Mark Ingram II has recorded 75.5 fantasy points this year (6.9 per game), good enough to place him among nulls and 96th overall in league-wide fantasy standings.
  • Marquez Callaway is 36th among receivers and 101st overall after scoring 73.2 fantasy points (averaging 7.3 per game) so far this season.
  • Trevor Siemian is the 106th-ranked fantasy player — and the 32nd-ranked quarterback — with 70.6 fantasy points (7.1 per game).

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