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Buffalo Bills vs. Indianapolis Colts NFL Betting Preview for Week 11

The Indianapolis Colts (5-5) are 7-point underdogs heading into their matchup on Sunday, November 21, 2021 against the Buffalo Bills (6-3). An over/under of 49.5 is set for the contest.

Bills Vs. Colts Odds

Bills vs Colts Betting Information
Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
Bills -7 -112 -108 49.5 -113 -108 -326 +258

Bills and Colts: Last Three Games

  • Buffalo is 1-1-1 against the spread in its last three games, and has a 2-1 straight-up record in those contests.
  • The Bills and their opponents have hit the over in one of those games.
  • The Bills’ last three games have ended with an average of 48.5 points scored. That’s 1.0 fewer point than this contest’s over/under.
  • Indianapolis is 1-2-0 against the spread in its past three games, and has a 2-1 straight-up record in those contests.
  • The Colts and their opponents have combined to hit the over in two of those games.
  • The past three Colts games averaged 1.5 fewer points (48.0) than this matchup’s over/under.

Bills and Colts: Betting Trends

  • Buffalo has covered the spread in a matchup five times this season (5-3-1).
  • In games they were favored in by 7 points or more so far this season, the Bills went 3-1-1 against the spread.
  • Buffalo’s games have gone over the total four times this season.
  • The Bills have won five of the eight games they were the moneyline favorite this season (62.5%).
  • When it has played as a moneyline favorite with odds of -326 or shorter, Buffalo has a 4-1 record (winning 80% of its games).
  • The Bills have an implied moneyline win probability of 76.5% in this game.
  • Indianapolis is 6-4-0 against the spread this season.
  • The Colts have a perfect 1-0 ATS record when playing as at least 7-point underdogs.
  • Indianapolis’ games have gone over the total six times this season.
  • The Colts have been underdogs in six games this season and won two (33.3%) of those contests.
  • Indianapolis has played as an underdog of +258 or more once this season and lost that game.


Over/Under Trends

  • Four Buffalo games this season have gone over Sunday’s total of 49.5 points.
  • This season, four of Indianapolis’ games have ended with a score higher than 49.5 points.
  • Together, the two teams combine for 57.9 points per game, 8.4 points more than the over/under of 49.5 for this matchup.
  • These two teams surrender a combined 38 points per game, 11.5 points less than this contest’s over/under.
  • This season the average total for Bills games is 49.4 points, 0.1 fewer than the over/under of 49.5 points for this contest.
  • The over/under for this matchup is 3.2 points more than the average over/under in Colts’ games this season (46.3 points).

Bills Players to Watch

  • Josh Allen is fourth overall among all players and fourth among all quarterbacks with 214.3 fantasy points (23.8 per game).
  • Stefon Diggs’ 99.0 total fantasy points (an average of 11.0 per game), are enough to rank him 58th overall and 13th among receivers.
  • So far this season, Emmanuel Sanders’ 77.6 total fantasy points make him the No. 83 fantasy player and No. 27 receiver. He averages 8.6 fantasy points per game.
  • Zack Moss’ fantasy season so far has him ranked 97th overall and 30th among running backs with 70.6 points (7.8 per game).

Colts Players to Watch

  • So far this season, Jonathan Taylor is the eighth-best fantasy player overall this season and the best fantasy running back with 182.0 fantasy points (18.2 per game).
  • Carson Wentz has racked up total 171.1 fantasy points this year (17.1 per game), which make him the 11th-ranked quarterback and the 14th-ranked player overall.
  • Michael Pittman Jr.’s 103.7 total fantasy points make him the No. 53 fantasy player and No. 10 receiver. He averages 10.4 fantasy points per game.
  • Zach Pascal has put together the 141st-ranked fantasy season (49th among receivers) with 50.8 fantasy points, averaging 5.1 per game.

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