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Los Angeles Rams vs. San Francisco 49ers NFL Betting Preview for Week 10

NFC West opponents meet when the Los Angeles Rams (7-2) visit the San Francisco 49ers (3-5) on Monday, November 15, 2021 at Levi’s Stadium. Los Angeles is favored by 3.5 points. The over/under is 50.5.

Rams Vs. 49ers Odds

Rams vs 49ers Betting Information
Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds Favorite Moneyline Underdog Moneyline
Rams -3.5 -107 -111 50.5 -110 -110 -181 +153

Rams and 49ers: Last Three Games

  • Los Angeles has not covered a spread (0-3-0) while going 2-1 overall in its past three games.
  • The final combined score of the last three Rams games surpassed the set total once.
  • The Rams’ last three games have ended with an average of 50.3 points scored. That’s 0.2 fewer points than this contest’s over/under.
  • San Francisco is 1-2-0 against the spread over its past three games, and has a 1-2 straight-up record in those matchups.
  • The final combined score of the past three 49ers games has surpassed the set total every time.
  • The last three 49ers games averaged 42.0 total points, 8.5 fewer points than this matchup’s point total.

Rams and 49ers: Betting Trends

  • Los Angeles is 4-5-0 against the spread this season.
  • The Rams are 2-5 ATS when playing as at least 3.5-point favorites.
  • Los Angeles games have finished with a final combined score above the over/under five times this season.
  • The Rams are 6-2 in games they were favored on the moneyline (winning 75% of those games).
  • When playing as a moneyline favorite with odds of -181 or shorter, Los Angeles has a 5-2 record (winning 71.4% of its games).
  • Based on this contest’s moneyline, the Rams’ implied win probability is 64.4%.
  • San Francisco has covered the spread in a matchup two times this season (2-6-0).
  • The 49ers are winless against the spread when they are 3.5-point underdogs or more (0-1).
  • This year, five of San Francisco’s games have gone over the point total.
  • The 49ers lost the only game they’ve played as the underdog this season.
  • San Francisco has played as an underdog of +153 or more once this season and lost that game.


Over/Under Trends

  • Los Angeles and its opponents have combined to outscore Monday’s total (50.5 points) four times this season.
  • This season, three of San Francisco’s games have finished with a combined score higher than 50.5 points.
  • Together, the two teams combine for 52.1 points per game, 1.6 points more than the point total of 50.5 for this matchup.
  • The 47.1 points per game these two teams allow their opponents to score on average this season are 3.4 fewer than the 50.5 total in this contest.
  • The Rams have seen a 50.8 average over/under in their games this season, 0.3 points more than the over/under in this contest.
  • A difference of 4.0 points separates this contest’s over/under (50.5 points) and the average total points bet in 49ers’ games (46.5 points) this season.

Rams Players to Watch

  • Matthew Stafford is the No. 6 fantasy player overall and the No. 6 fantasy quarterback with 196.5 points (averaging 21.8 per game).
  • Cooper Kupp has put up 161.4 fantasy points this year (17.9 per game), enough to place him 17th overall and first among receivers in league-wide fantasy standings.
  • So far this season, Darrell Henderson’s 112.6 total fantasy points make him the No. 41 fantasy player and No. 12 running back. He averages 12.5 fantasy points per game.
  • Van Jefferson is working on the 117th-ranked fantasy season (40th among receivers) with 61.3 fantasy points, averaging 6.8 per game.

49ers Players to Watch

  • So far this season, Deebo Samuel is 37th overall among all players and fourth among all receivers with 116.4 fantasy points (14.6 per game).
  • Jimmy Garoppolo has collected total 109.5 fantasy points this year (13.7 per game), which make him the 26th-ranked quarterback and the 45th-ranked player overall.
  • Elijah Mitchell’s 72.2 total fantasy points make him the No. 93 fantasy player and No. 28 running back. He averages 9.0 fantasy points per game.
  • Trey Lance has put together the 155th-ranked fantasy season (35th among quarterbacks) with 47.5 fantasy points, averaging 5.9 per game.

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